Coli urinal Effervescent Granules treatment of chronic 60g are used in the prophylaxis and treatment of chronic or recurrent lower urinary tract infections and asymptomatic bacteriuria. Do not take Piperazine/Hexamine/Khellin effervescent granules : Hypersensitivity to the active substance or to any of the excipients. Epilepsy or severe renal impairment and should be given with care to patients with neurological disturbances. It should also be avoided or given with extreme caution in patients with hepatic impairment. During pregnancy and lactation. Severe dehydration, metabolic acidosis, or gout.