Co-Aprovel Treating blood pressure 300 /12.5 mg Tablet 28pcs It is a combination of Irbesartan, an angiotensin II receptor antagonist, and Hydrochlorothiazide, a thiazide diuretic, indicated for hypertension: In patients not adequately controlled with monotherapy. As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goal. Do not take Irbesartan/Hydrochlorothiazide if: Hypersensitivity to Irbesartan or hydrochlorothiazide Hypersensitivity to sulfonamide-derived drugs (like sulfamethoxazole/trimethoprim, sulfasalazine) Anuria present (not enough urine production) Renal impairment Liver impairment