Aprovasc 300/5 Mg 28 Tab Pharmacodynamic properties of each drug, irbesartan and amlodipine, are in favor of an addition of antihypertensive effects when considered in combination versus alone: both AT1 receptor antagonists and calcium channel blockers lower blood pressure by reducing peripheral resistance, but calcium influx blockade and reduction of angiotensin II vasoconstriction are complementary mechanisms.It is the best product for Hypertension treatment .